| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7801901 | European Journal of Medicinal Chemistry | 2013 | 46 Pages |
Abstract
⺠Cytotoxic effect of three series of dehydroepiandrosterone derivatives was determined. ⺠The following cancer cell lines were used in this study: PC-3, MCF-7 and SKLU-1. ⺠The steroids with triazole ring produced higher cytotoxicity than those with pyrazole. ⺠Electronegative groups in the ester moiety increased cytotoxicity in cell lines. ⺠Steroids 4a, 4e, 4i-4k, 5o and 5f exhibited the highest cytotoxic effect.
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Authors
Mariana Garrido, Marisa Cabeza, Francisco Cortés, José Gutiérrez, Eugene Bratoeff,