| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7801995 | European Journal of Medicinal Chemistry | 2013 | 7 Pages |
Abstract
A structure-based virtual screening strategy has been applied for the discovery of natural hit structures able to inhibit Integrase-LEDGF/p75 interaction.
Keywords
CCDRMSDPDBLEDGFPPIIBDMM-GBSAHIV-1 integraseLEDGF/p75IntegraseAIDSProtein–protein interaction inhibitorsProtein–protein interactionintegrase binding domaincatalytic core domainMolecular dynamicsacquired immunodeficiency syndromeVirtual screeninglens epithelium-derived growth factorNatural productsroot mean square deviationHIV-1Human immunodeficiency virus type 1Protein Data Bank
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Laura De Luca, Francesca Morreale, Frauke Christ, Zeger Debyser, Stefania Ferro, Rosaria Gitto,