Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7802332 | European Journal of Medicinal Chemistry | 2012 | 8 Pages |
Abstract
⺠17 Novel bis(POM) prodrugs acyclic nucleosides were synthesized and characterized. ⺠Mitsunobu reaction was used between purine bases and a new phosphonate synthon 3. ⺠EC50 values of some molecules were in (sub)micromolar range against DNA virus and HIV-2.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ugo Pradère, Vincent Roy, Aurélien Montagu, Ozkan Sari, Manabu Hamada, Jan Balzarini, Robert Snoeck, Graciela Andrei, Luigi A. Agrofoglio,