| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802373 | European Journal of Medicinal Chemistry | 2012 | 11 Pages |
Abstract
⺠Compared all the metabolic pathways of humans and plague pathogen Yersinia pestis. ⺠Identified 245 potential drug targets in the pathogen (25 metabolic choke points). ⺠Targets are not homologs of human proteins and are vital for bacterium's survival. ⺠Structure of MurE ligase, a choke point enzyme and ideal drug target, was modeled. ⺠Model used to identify potential lead molecule through docking studies.
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Authors
Aditya Sharma, Archana Pan,