| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802386 | European Journal of Medicinal Chemistry | 2012 | 6 Pages |
Abstract
⺠All of the 26 new compounds based on CL-385319 inhibit H5N1 pseudovirus. ⺠Compound 1l was the most active inhibitor with an IC50 of 0.22 μM ⺠Mechanism study showed that compound 1l target the H5-typed hemagglutinin. ⺠3-Fluoro-5-(trifluoromethyl)benzamide is important for the inhibitory activity.
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Authors
Zhibo Zhu, Runming Li, Gaokeng Xiao, Zhipeng Chen, Jie Yang, Qiuhua Zhu, Shuwen Liu,