| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802394 | European Journal of Medicinal Chemistry | 2012 | 9 Pages |
Abstract
⺠Novel 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles were synthesized. ⺠Structure was confirmed by a single-crystal X-ray diffraction. ⺠These compounds showed promising in vitro inhibitory activities against PI3Kα. ⺠This series exhibited significant anti-proliferative effects in various human cancer cell lines.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors](/preview/png/7802394.png "First Page Preview: Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors")
Authors
Amélie Bruel, Cédric Logé, Marie-Ludivine de Tauzia, Myriam Ravache, Rémy Le Guevel, Christiane Guillouzo, Jean-François Lohier, Jana Sopkova-de Oliveira Santos, Olivier Lozach, Laurent Meijer, Sandrine Ruchaud, Hélène Bénédetti,