The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives

► Arylamino quinolines containing N-donor group were designed and profiled in silico. ► A series of tetrazole-based compounds 4.12a-4.14f were then synthesized. ► Biological activity is likely influenced by the substituent on the tetrazole ring. ► Compounds 4.12b and 4.12d were identified as the most promising in this series.