| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802416 | European Journal of Medicinal Chemistry | 2012 | 12 Pages |
Abstract
⺠We prepared imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives. ⺠The structure and biological activity relationship was evaluated. ⺠Many exhibited potent anti-proliferative and CDK9 inhibitory activities. ⺠A lead 18b activated caspase 3/7 activity and induced apoptosis.
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![Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents](/preview/png/7802416.png "First Page Preview: Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents")
Authors
Pawel M. Lukasik, Sherifa Elabar, Frankie Lam, Hao Shao, Xiangrui Liu, Abdullah Y. Abbas, Shudong Wang,