| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802437 | European Journal of Medicinal Chemistry | 2012 | 12 Pages |
Abstract
⺠Different groups were inserted on the side rings of symmetric naphthalene diimides. ⺠Significant antitumor activity with pIC50 values ranging from 6 to 7. ⺠The most potent compound 20 was characterized by a 2,3,4-trimethoxy substituent. ⺠It inhibited Taq polymerase, ERKs phosphorylation, and downregulated ERK 2 protein.
Keywords
DTPNCIdsDNAdouble strand DNANDIPDBEtBrNACERKTRAPN-acetylcysteineethidium bromideBrdUbromodeoxyuridineCircular dicroismNaphthalene diimidesCytotoxicityextracellular signal regulated kinaseAnticancerMultitarget-directed ligandsNational Cancer InstituteProtein Data BankTelomeric repeat amplification protocol
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrea Milelli, Vincenzo Tumiatti, Marialuisa Micco, Michela Rosini, Guendalina Zuccari, Lizzia Raffaghello, Giovanna Bianchi, Vito Pistoia, J. Fernando DÃaz, Benet Pera, Chiara Trigili, Isabel Barasoain, Caterina Musetti, Marianna Toniolo,