| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802459 | European Journal of Medicinal Chemistry | 2012 | 11 Pages |
Abstract
⺠Thirty-two 2-substituted ethenesulfonic acid ester derivatives were prepared. ⺠Most compounds exhibited excellent inhibitory activities against PTP1B with IC50 values of 1.3-15.1 μM. ⺠The substitution at the aromatic center and the length of linker markedly affected the inhibitory activity against PTP1B. ⺠Most chemicals have low cytotoxicity for COS-7 cell with IC50 values >100 μM. ⺠Compounds 43 and 36 marked 10- and 20-fold selectivity over TCPTP respectively.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jingbao Liu, Faqin Jiang, Yan Jin, Yong Zhang, Jingjing Liu, Wenlu Liu, Lei Fu,