| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802542 | European Journal of Medicinal Chemistry | 2012 | 12 Pages |
Abstract
⺠A series of 2-substituted nitroquinolines was prepared and studied concerning their in vitro antileishmanial properties. ⺠The 2-hydroxy-8-nitroquinoline (molecule 21) appeared as a hit molecule on both pro- and amastigotes stages of L. donovani. ⺠Hit molecule 21, non-toxic on 2 different cell lines also appeared as a selective anti-infectious agent among protozoa.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lucie Paloque, Pierre Verhaeghe, Magali Casanova, Caroline Castera-Ducros, Aurélien Dumètre, Litaty Mbatchi, Sébastien Hutter, Manel Kraiem-M'Rabet, Michèle Laget, Vincent Remusat, Sylvain Rault, Pascal Rathelot, Nadine Azas, Patrice Vanelle,