| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802544 | European Journal of Medicinal Chemistry | 2012 | 8 Pages |
Abstract
⺠Three chloro-indolic isomers were synthesized and evaluated on hTDO. ⺠The single-crystal X-ray analyses of two of them revealed non-planar structures. ⺠The position of the Cl atom does not notably affect the electronic delocalization. ⺠The non-coplanarity plays a more important role in the crystalline packing. ⺠Physico-chemical properties led to an understanding of mechanism of TDO inhibition.
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Authors
Laurence Moineaux, Sophie Laurent, Jérémy Reniers, Eduard DoluÅ¡iÄ, Moreno Galleni, Jean-Marie Frère, Bernard Masereel, Raphaël Frédérick, Johan Wouters,