| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802545 | European Journal of Medicinal Chemistry | 2012 | 10 Pages |
Abstract
⺠We synthesized and evaluated carnosine nitrooxy derivatives as antioxidant and organ protective agents. ⺠New compounds showed multifactorial antioxidant activity in vitro. ⺠Both NO and des-NO carnosine derivatives protect from ischaemia/reperfusion injury in vivo. ⺠One model NO-donor carnosine derivative was able to lower TNF-α in vivo.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Massimo Bertinaria, Barbara Rolando, Marta Giorgis, Gabriele Montanaro, Elisabetta Marini, Massimo Collino, Elisa Benetti, Pier Giuseppe Daniele, Roberta Fruttero, Alberto Gasco,