| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802546 | European Journal of Medicinal Chemistry | 2012 | 10 Pages |
Abstract
⺠Selection and optimization of inhibitors based on MtOPRT kinetic mechanism. ⺠Identification of MtOPRT inhibitors with nanomolar inhibition constant values. ⺠In vitro kinetic assays to characterize binding mode of inhibitors. ⺠Thermodynamic discrimination profiles of inhibitors assessed by ITC. ⺠Inhibitory activity of 13 is likely due to entropy optimization.
Keywords
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Organic Chemistry
Authors
Ardala Breda, Pablo Machado, Leonardo Astolfi Rosado, André Arigony Souto, Diógenes Santiago Santos, Luiz Augusto Basso,