Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7802549 | European Journal of Medicinal Chemistry | 2012 | 15 Pages |
Abstract
⺠Fifteen synthesized coumarin compounds were examined as in vivo anticoagulants. ⺠Four compounds, 2b, 4c, 5c and 9c, presented in vivo activity. ⺠Coumarin molecular target, VKORC1, was homology-modeled. ⺠Results were discussed using 3D-QSAR, molecular docking and DFT mechanistic studies. ⺠Coumarin metabolic pathways were obtained.
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Authors
Milan MladenoviÄ, Mirjana MihailoviÄ, Desanka BogojeviÄ, Nenad VukoviÄ, Slobodan Sukdolak, Sanja MatiÄ, Neda NiÄiforoviÄ, Vladimir MihailoviÄ, Pavle MaÅ¡koviÄ, Miroslav M. VrviÄ, Slavica SolujiÄ,