| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802561 | European Journal of Medicinal Chemistry | 2012 | 8 Pages |
Abstract
⺠The ability of urea-derivatives (4a-e) to be recognized by p38 MAPK was determined by docking studies. ⺠Compound 4e showed a better score value compared to the prototype GK-00687. ⺠Anti-inflammatory and analgesic activities of compound 4e were demonstrated. ⺠Compound 4e is a weak inhibitor of TNF-alfa production and p38 MAPK.
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Authors
Raquel de Oliveira Lopes, Nelilma Correia Romeiro, Cleverton Kleiton F. de Lima, Leandro Louback da Silva, Ana Luisa Palhares de Miranda, Paulo Gustavo B.D. Nascimento, Fernando Q. Cunha, Eliezer J. Barreiro, LÃdia Moreira Lima,