| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802562 | European Journal of Medicinal Chemistry | 2012 | 9 Pages |
Abstract
⺠Two natural pyranochalcones and their derivatives were synthesized and evaluated for anti-inflammatory activities. ⺠5b showed remarkable in vitro and in vivo anti-inflammatory activity comparable to indomethacin. ⺠Molecular docking was employed to investigate the binding mode of the significant inhibitor 5b. ⺠Structure-activity relationship is discussed.
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Authors
Fei Peng, Guangcheng Wang, Xiuxia Li, Dong Cao, Zhuang Yang, Liang Ma, Haoyu Ye, Xiaolin Liang, Yan Ran, Jinying Chen, Jingxiang Qiu, Caifeng Xie, Chongyang Deng, Mingli Xiang, Aihua Peng, Yuquan Wei, Lijuan Chen,