Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors

► Design of 2nd series of new triazole-based compounds as mPGES-1 and 5-LO inhibitors. ► Synthesis of 2-16 performed by click chemistry and Suzuki cross-coupling reaction. ► Identification of 10, 11 and 14-15 as potent mPGES-1 inhibitors. ► 5, 10, 12 and 14-16 emerged as 5-LO inhibitors.