| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802568 | European Journal of Medicinal Chemistry | 2012 | 19 Pages |
Abstract
⺠Identification of a 3-phenylisoxazole scaffold as potent inhibitor of hDGAT1. ⺠DGAT1 activity of 3-phenylisoxazoles translates to in vivo triglyceride reduction. ⺠3-Phenylisoxazole analogs with improved cLogP result in improved solubility. ⺠Compound 40a may serve as a new lead for developing newer anti-obesity agents.
Keywords
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Organic Chemistry
Authors
Ravindra D. Jadhav, Kishorkumar S. Kadam, Shivaji Kandre, Tandra Guha, M. Mahesh Kumar Reddy, Manoja K. Brahma, Nitin J. Deshmukh, Amol Dixit, Lalit Doshi, Nisha Potdar, Arno A. Enose, Ram A. Vishwakarma, H. Sivaramakrishnan, Shaila Srinivasan,