Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7802576 | European Journal of Medicinal Chemistry | 2012 | 10 Pages |
Abstract
⺠A series of quercetin derivatives with various O-3 substituents were synthesized. ⺠They have not any inherent cytotoxicity to cancer and normal mouse fibroblast cells. ⺠O-3 substituent played a key role for determining P-gp- and BCRP-modulating activity. ⺠Compound 17 was equipotent against both P-gp and BCRP.
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Authors
Jian Yuan, Iris L.K. Wong, Tao Jiang, Si Wen Wang, Tao Liu, Bin Jin Wen, Larry M.C. Chow, Biao Wan Sheng,