| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802582 | European Journal of Medicinal Chemistry | 2012 | 13 Pages |
Abstract
⺠Heterocyclic rings at the 6-position gave good AMPA receptor affinity. ⺠Derivative 8 (R6 = 1,2,4-triazol-4-yl) showed high AMPA receptor affinity. ⺠Derivative 3 showed the best affinity and selectivity for the kainate receptor. ⺠Derivatives 3 and 8 were effective neuroprotective agents in rat models of cerebral ischemia. ⺠Compound 8 showed anticonvulsant effect in pentylenetetrazole-induced convulsions.
Keywords
N-methyl-d-aspartateiGluRsNBQXfEPSPPTZMK-801NMDAOGDaCSFAMPADCKA5,7-dichlorokynurenic acidAMPA receptor antagonistsAnoxic depolarizationNeuroprotective agentsartificial cerebrospinal fluidOxygen and glucose deprivationField excitatory postsynaptic potentialPropidium iodidePentylenetetrazoleKainateGluglutamateionotropic glutamate receptors
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vittoria Colotta, Ombretta Lenzi, Daniela Catarzi, Flavia Varano, Lucia Squarcialupi, Chiara Costagli, Alessandro Galli, Carla Ghelardini, Anna Maria Pugliese, Giovanna Maraula, Elisabetta Coppi, Domenico E. Pellegrini-Giampietro, Felicita Pedata,