| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802583 | European Journal of Medicinal Chemistry | 2012 | 14 Pages |
Abstract
⺠Quantification of the binding interactions of STLC in complex with Eg5. ⺠SAR study describing new analogues of STLC with modification to the trityl system. ⺠Novel analogues with IC50 values <100 nM against Eg5. ⺠SAR of P-glycoprotein induced resistance for this class of compounds.
Keywords
DMEMEtOAcEg5KSPPGPHRMSGI50STLCr.m.s.dEt2OMM/PBSADulbecco’s modified Eagle mediumP-glycoproteinEthyl acetateDiethyl etherMolecular dynamicsStructureHourhigh-resolution mass spectrometryAntimitotic agentsMethanolMeOHMolecular Mechanics/Poisson-Boltzmann Surface Arearoot mean square deviationResprestrained electrostatic potentialKinesin spindle protein
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Murad N. Abualhasan, James A.D. Good, Kitiyaporn Wittayanarakul, Nahoum G. Anthony, Giacomo Berretta, Oliver Rath, Frank Kozielski, Oliver B. Sutcliffe, Simon P. Mackay,