Liposomes as vehicles for water insoluble platinum-based potential drug: 2-(4-(Tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II)

Article ID	Journal	Published Year	Pages	File Type
7802591	European Journal of Medicinal Chemistry	2012	6 Pages	PDF

Abstract

âº Liposomal formulation of water insoluble platinum(II) based drug, LipoTHP-C11. âº LipoTHP-C11 effective than cisplatin on cisplatin resistant TGCT 1411HP cells. âº LipoTHP-C11 effective than cisplatin on anaplastic thyroid carcinoma SW1736 cells. âº LipoTHP-C11 attractive candidate for further assessment inÂ vivo as antitumor agent

Keywords

Selectivity cisplatin Antitumoral activity Liposomes Platinum(II) complexes

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Liposomes as vehicles for water insoluble platinum-based potential drug: 2-(4-(Tetrahydro-2H-pyran-2-yloxy)-undecyl)-propane-1,3-diamminedichloroplatinum(II)

Authors

Goran N. KaluÄeroviÄ, Andrea Dietrich, Harish Kommera, Judith Kuntsche, Karsten Mäder, Thomas Mueller, Reinhard Paschke,