Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7802594 | European Journal of Medicinal Chemistry | 2012 | 6 Pages |
Abstract
⺠Twelve linear peptides derived from E. coli ParE protein were synthesized. ⺠Four of the twelve peptides behaved as good bacterial topoisomerases inhibitors. ⺠ParELC10 was the most potent inhibitor for both DNA gyrase and topoisomerase IV. ⺠A structural change in ParELC10 resulted in a less active peptide, but with inhibitory activity on human topoisomerase II.
Related Topics
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Authors
Luiz Carlos Bertucci Barbosa, Saulo Santesso Garrido, Anderson Garcia, Davi Barbosa Delfino, Laura do Nascimento Santos, Reinaldo Marchetto,