| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802598 | European Journal of Medicinal Chemistry | 2012 | 11 Pages |
Abstract
⺠Two new pyrazolic series of the marine granulatimide alkaloids were prepared. ⺠A pyrolic series of granulatimide was completed. ⺠The most interesting compounds exhibited growth inhibitory activity with IC50 of 10 μM. ⺠A unique compound revealed a G2 checkpoint abrogating effect similar to that observed with the natural alkaloids. ⺠Some compounds have shown weak to actual inhibitory activities with poor selectivity in a small kinase panel.
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Authors
Sébastien Deslandes, Delphine Lamoral-Theys, Céline Frongia, Stefan Chassaing, Céline Bruyère, Olivier Lozach, Laurent Meijer, Bernard Ducommun, Robert Kiss, Evelyne Delfourne,