| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802607 | European Journal of Medicinal Chemistry | 2012 | 7 Pages |
Abstract
⺠Steroidal 2-amino-2-deoxy-β-d-glucopyranoside derivatives were synthesized starting from steroidal sapogenins. ⺠Antiproliferative activity against CaSki, HeLa and ViBo cells is described. ⺠Proliferative potential on lymphocytes was not negatively affected. ⺠Cytotoxicity was tested in tumoral and healthy cells to demonstrate selectivity. ⺠The hydrochloride salt from diosgenin showed better activity than the N-acetylated analog.
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Authors
MarÃa A. Fernández-Herrera, Hugo López-Muñoz, José M.V. Hernández-Vázquez, Luis Sánchez-Sánchez, MarÃa L. Escobar-Sánchez, B. Mario Pinto, Jesús Sandoval-RamÃrez,