Article ID Journal Published Year Pages File Type
7802608 European Journal of Medicinal Chemistry 2012 12 Pages PDF
Abstract
► A total of 19 novel steroidal 5α-reductase inhibitors were synthesized. ► In vitro biological evaluation against HEK cells was carried out. ► Compounds 21-23 and 25 were found to be potent 5α-reductase II inhibitors. ► Compound 13 was found to be potent inhibitor of 5α-reductase I enzyme.
Keywords
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach
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