| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802615 | European Journal of Medicinal Chemistry | 2012 | 9 Pages |
Abstract
⺠Lapachol (1) is a potent bioactive compound with several therapeutic applications. ⺠Oxidation by Jacobsen catalyst model can mimic the reactions of cytochrome P450. ⺠Mn(salen) catalysed oxidation of lapachol led to the formation of eleven products. ⺠α-Lapachone and dehydro-α-lapachone detected in vivo in rats treated with lapachol.
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Authors
Michael Niehues, Valéria Priscila Barros, Flávio da Silva Emery, Marcelo Dias-Baruffi, Marilda das Dores Assis, Norberto Peporine Lopes,