| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802617 | European Journal of Medicinal Chemistry | 2012 | 11 Pages |
Abstract
⺠An indole library of 19 compounds was synthesized and evaluated against both COXs. ⺠One compound was found to be active at 50 μM, showing 70% COX-2 inhibition. ⺠The docking studies were performed and were in agreement with the experimental data. ⺠For the first time STD-NMR experiments were realized with COXs. ⺠Identification of structural motifs that have a stronger interaction with COXs.
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Authors
Mónica S. Estevão, LuÃsa C.R. Carvalho, Marisa Freitas, Ana Gomes, Aldino Viegas, João Manso, Stefan Erhardt, Eduarda Fernandes, Eurico J. Cabrita, M. Manuel B. Marques,