Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells

► Hybrid compounds between diazoxide and cromakalim, two potassium channel openers, were synthesized. ► They were evaluated on three KATP channel-expressing tissues (pancreatic β-cells, aorta, uterus). ► Strong myorelaxant activity on uterus, but not on rat aorta, was found with 6-bromo-substituted dihydrobenzopyran hybrid compounds. ► None of these compounds were found to exert any inhibitory activity on insulin release.