| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802624 | European Journal of Medicinal Chemistry | 2012 | 13 Pages |
Abstract
⺠Cinnamic acid/4-aminoquinoline hybrids were synthesized as dual-action drugs. ⺠Hybrids were linked via a retro-enantio dipeptide. Its absence was also evaluated. ⺠Their power to inhibit hemozoin growth, falcipain and blood-stage Pf were assessed. ⺠Hybrids with dipeptide were active against blood-stage Pf and hemozoin growth. ⺠Molecules without spacer were better falcipain-2 inhibitors.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bianca C. Pérez, Cátia Teixeira, Marta Figueiras, Jiri Gut, Philip J. Rosenthal, José R.B. Gomes, Paula Gomes,