| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802626 | European Journal of Medicinal Chemistry | 2012 | 7 Pages |
Abstract
⺠A group of chalcone/NO-donating hybrids were prepared and identified by different spectroscopic techniques. ⺠The tested NO-donating compounds exhibited from mild to strong cytotoxic activity. ⺠The nitrate ester 3a exhibited moderate selectivity toward colon cancer subpanel with selectivity ratio of 5.87 at TGI level. ⺠The novel synthesized NO-donating hybrids represent a significant strategy against cancer.
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Authors
Mai A.E. Mourad, Mohamed Abdel-Aziz, Gamal El-Din A.A. Abuo-Rahma, Hassan H. Farag,