| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802635 | European Journal of Medicinal Chemistry | 2011 | 10 Pages |
Abstract
⺠Aminoacyl tRNA synthetases (aaRSs) are a key component in protein synthesis. ⺠AaRS inhibitors make up a potential class of new antimicrobials. ⺠Several aaRS inhibitors are in clinical development. ⺠Aminoacyl sulfamoyladenosines (aaSAs) for a long time already have been evaluated as high-potential antibiotics. ⺠Improvement of the bioavailability problem of aaSAs is under investigation. ⺠The here discussed compounds will further establish aaRSs as a valuable target for development of antibiotics.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gaston H.M. Vondenhoff, Arthur Van Aerschot,