| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802638 | European Journal of Medicinal Chemistry | 2011 | 7 Pages |
Abstract
⺠By means of structure-based bioisosterism, triazolone was used as a new bioisostere of oxygen atom. This type of bioisosteric replacement can improve the water solubility without loss of hydrogen-bonding interaction with the target enzyme. ⺠Several triazolone-containing triazoles (such as 11d, 11j, 11p and 11q) showed higher antifungal activity and broader spectrum than fluconazole. ⺠Compounds 11c and 11i showed good activity toward azole-resistant clinical isolate.
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Organic Chemistry
Authors
Chunquan Sheng, Xiaoying Che, Wenya Wang, Shengzheng Wang, Yongbing Cao, Zhenyuan Miao, Jianzhong Yao, Wannian Zhang,