| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802665 | European Journal of Medicinal Chemistry | 2011 | 7 Pages |
Abstract
⺠We synthesized the enantiomers of hCB1 inverse agonist 13R and 13S. ⺠Results indicated that the (R)-enantiomer is more active. ⺠In vivo study showed enhanced antagonistic activity for hCB1, and better bio-efficacy.
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![Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists](/preview/png/7802665.png "First Page Preview: Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists")
Authors
Linghuan Gao, Min Li, Tao Meng, Hongli Peng, Xin Xie, Yongliang Zhang, Yu Jin, Xin Wang, Libo Zou, Jingkang Shen,