Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships

► PIB-SA is new class of antimitotics exhibiting a new molecular scaffold. ► PIB-SAs arrest the cell cycle progression in G2/M phase. ► PIB-SAs are potent antimicrotubule agents binding to the C-BS. ► PIB-SAs were not or only slightly affected by chemoresistance. ► PIB-SAs exhibit potent antitumoral and antiangiogenic activity in the CAM assay.