| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802782 | European Journal of Medicinal Chemistry | 2011 | 12 Pages |
Abstract
⺠16 new MurD inhibitors of 4 structural series were prepared and evaluated against MurD from E. coli. ⺠Several compounds exhibited promising inhibitory activities with IC50 values up to 28 μM. ⺠The most potent compound 26 had an IC50 of 28 μM on MurD from E. coli. ⺠Crystal structures of MurD in complex with two new inhibitors (compounds 23 and 51) were obtained. ⺠Inhibitor 37 displays a weak antibacterial activity against S. aureus and E. faecalis.
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Authors
Nace Zidar, Tihomir TomaÅ¡iÄ, Roman Å ink, Andreja KovaÄ, Delphine Patin, Didier Blanot, Carlos Contreras-Martel, Andréa Dessen, Manica Müller Premru, Anamarija Zega, Stanislav Gobec, Lucija Peterlin MaÅ¡iÄ, Danijel Kikelj,