| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802813 | European Journal of Medicinal Chemistry | 2011 | 7 Pages |
Abstract
⺠New TACE inhibitors based on BMS-566394 scaffold were synthesized. ⺠Effect of replacement of the central phenyl ring with heteroaryl rings on the TACE inhibitory activity was studied. ⺠In vitro potency increased when central ring was pyridine whereas decreased in case of five member heterocycles. ⺠This observation was supported by in silico molecular modeling studies.
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Authors
Prabal Sengupta, Chetan S. Puri, Hemant A. Chokshi, Chetana K. Sheth, Ajay S. Midha, Trinadha Rao Chitturi, Rajamannar Thennati, Prashant R. Murumkar, Mange Ram Yadav,