| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802841 | European Journal of Medicinal Chemistry | 2011 | 6 Pages |
Abstract
⺠Thiazolo-diazepine, benzothiazolo-diazepine and benzooxazolo-diazepine analogues were synthesized. ⺠Anticonvulsant activity of the new compounds was evaluated. ⺠Compounds 12, 20, and 24 showed 100% protection against PTZ-induced seizures. ⺠Compounds 12, 20, and 24 proved to act as GABAA receptor agonist.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and anticonvulsant activity of some new thiazolo[3,2-a][1,3]diazepine, benzo[d]thiazolo[5,2-a][12,6]diazepine and benzo[d]oxazolo[5,2-a][12,6]diazepine analogues](/preview/png/7802841.png "First Page Preview: Synthesis and anticonvulsant activity of some new thiazolo[3,2-a][1,3]diazepine, benzo[d]thiazolo[5,2-a][12,6]diazepine and benzo[d]oxazolo[5,2-a][12,6]diazepine analogues")
Authors
Hussein I. El-Subbagh, Ghada S. Hassan, Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Adnan A. Kadi, Abdulrahman M. Al-Obaid, Othman A. Al-Shabanah, Mohamed M. Sayed-Ahmed,