Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7802881 | European Journal of Medicinal Chemistry | 2011 | 11 Pages |
Abstract
⺠β-Tetrahydrocarbolinecarbonyldrazines were aromatized to β-carbolinecarbonyl- hydrazines. ⺠The aromatization decreased the proximity of the side chain to the carboline-cycle. ⺠The aromatization increased the in vitro anti-platelet aggregation activity. ⺠The aromatization increased the in vivo anti-thrombotic activity. ⺠These could be understood with a 3D QSAR analysis.
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Authors
Chunyu Li, Xiaoyi Zhang, Ming Zhao, Yuji Wang, Jianhui Wu, Jiawang Liu, Meiqing Zheng, Shiqi Peng,