| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7802961 | European Journal of Medicinal Chemistry | 2011 | 5 Pages |
Abstract
⺠Forty-seven GJP14 derivatives were designed and synthesized. ⺠Anti-prion activity of GJP14 derivatives was evaluated in TSE-infected cells. ⺠The derivatives bearing an N-ortho-halobenzyl group exhibited an improved activity. ⺠(S)-Enantiomer was identified as the eutomer.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tsutomu Kimura, Junji Hosokawa-Muto, Kenji Asami, Toshiaki Murai, Kazuo Kuwata,