| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803007 | European Journal of Medicinal Chemistry | 2011 | 7 Pages |
Abstract
⺠Investigation of bioisosteric alternative scaffold of antiviral arylmethyloxy-ADKs. ⺠2,6-Bis-arylmethyloxy-5-hydroxychromones active against both HCV and SCV. ⺠Antiviral activity against HCV (EC50 = 4 μM). ⺠Inhibition of SCV NTPase (IC50 = 4 μM) as well as ATPase activity (IC50 = 11 μM). ⺠Potential platform structure for multi-target or broad-spectrum antivirals.
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Authors
Mi Kyoung Kim, Mi-Sun Yu, Hye Ri Park, Kyung Bo Kim, Chaewoon Lee, Suh Young Cho, Jihoon Kang, Hyunjun Yoon, Dong-Eun Kim, Hyunah Choo, Yong-Joo Jeong, Youhoon Chong,