| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803080 | European Journal of Medicinal Chemistry | 2011 | 15 Pages |
Abstract
⺠We discovered novel Piperazinylpyrimidine derivatives as antitumor agents. ⺠4 and 15 are selective cytostatic and 16 is global cytotoxic against NCI-60 panel. ⺠15 is a promising preclinical candidate investigated against in vivo models. ⺠4 and 15 selectively inhibits the growth of basal-like breast cancer cell lines. ⺠4, 15, and 16 are selective binders and/or inhibitors of certain kinase subfamilies
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Authors
Hassan M. Shallal, Wade A. Russu,