| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803088 | European Journal of Medicinal Chemistry | 2011 | 15 Pages |
Abstract
⺠Pharmacomodulation of natural alkaloids to improve their profiles as anticancer agents. ⺠New generation of aza-analogues: benzo[c]phenanthrolines and benzo[c]phenanthrolinones. ⺠Introduction of dialkylaminoalkyl chains. ⺠Replacement of a benzene by a pyridine. ⺠Increased cytotoxicity and DNA affinity.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents](/preview/png/7803088.png "First Page Preview: Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents")
Authors
Constance Genès, Gaëlle Lenglet, Sabine Depauw, Raja Nhili, Soizic Prado, Marie-Hélène David-Cordonnier, Sylvie Michel, François Tillequin, François-Hugues Porée,