New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation

► New acetylcholinesterase inhibitors in the triterpene series were synthesized. ► Some compounds have humanAChE IC50 values in the nanomolar range. ► Some analogs showed ability to block the AChE-induced Aβ aggregation. ► A docking study and molecular dynamics simulations were done. ► These compounds interact with both catalytic and peripheral sites of AChE.