| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803100 | European Journal of Medicinal Chemistry | 2011 | 7 Pages |
Abstract
⺠Various 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea (5a-p) were synthesized and evaluated. ⺠Compound 5f was found active in MES screening while compounds 5h, 5i, 5k and 5l showed significant anticonvulsant activity in both the screenings and were devoid of any neurotoxicity. ⺠Compound 5h and 5i showed marked protection at 300 mg/kg against MES and scPTZ screening. ⺠In 6 Hz screening compounds 5h and 5i showed significant protection.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nadeem Siddiqui, M. Shamsher Alam, James P. Stables,