| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7803107 | European Journal of Medicinal Chemistry | 2011 | 15 Pages |
Abstract
⺠Fluorinated antagonists for the NR2B subunit of the NMDA receptors were developed. ⺠Two PET radiotracers containing the 4-(4-[18F]fluorobenzyl)piperidine moiety were synthesized. ⺠The in vivo evaluation by PET imaging demonstrated radiodefluorination. ⺠Metabolism of the 4-(4-[18F]fluorobenzyl)piperidine was studied by LC-MS.
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
![Synthesis, evaluation and metabolic studies of radiotracers containing a 4-(4-[18F]-fluorobenzyl)piperidin-1-yl moiety for the PET imaging of NR2B NMDA receptors](/preview/png/7803107.png "First Page Preview: Synthesis, evaluation and metabolic studies of radiotracers containing a 4-(4-[18F]-fluorobenzyl)piperidin-1-yl moiety for the PET imaging of NR2B NMDA receptors")
Authors
Romain Labas, Gwénaëlle Gilbert, Olivier Nicole, Martine Dhilly, Ahmed Abbas, Olivier Tirel, Alain Buisson, Joël Henry, Louisa Barré, Danièle Debruyne, Franck Sobrio,