Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7803109 | European Journal of Medicinal Chemistry | 2011 | 20 Pages |
Abstract
⺠Synthesis of some 2-furano-4(3H)-quinazolinones, diamides (open ring quinazolines), quinoxalines and their biological evaluation as antitumor agents using National Cancer Institute (NCI) disease oriented antitumor screen protocol investigated. ⺠Seventeen compounds were granted NSC code. ⺠3-(2-chloro benzylideneamine)-2-(furan-2-yl) quinazoline-4(3h)-one 21 (NSC D-753439/1) was found to be the most active candidate of the series at five dose level. ⺠Rational approach and QSAR techniques enabled the understanding of the pharmacophoric requirement for quinazoline, diamides (open ring quinazolines) and quinoxaline derivatives.
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Authors
Malleshappa N. Noolvi, Harun M. Patel, Varun Bhardwaj, Ankit Chauhan,