Article ID Journal Published Year Pages File Type
7803114 European Journal of Medicinal Chemistry 2011 11 Pages PDF
Abstract
► Natural products, moracins O and P, as leads for development of HIF-1α inhibitor. ► We examined structure-activity relationship study of benzofuran based moracin derivatives using cell-based HRE assay. ► The primary activity of the represented compound was confirmed by biochemical methods. ► In this study we conclude that 2-arylbenzofuran ring and the (R)-configuration of the core scaffold is important for activity.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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