Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7803114 | European Journal of Medicinal Chemistry | 2011 | 11 Pages |
Abstract
⺠Natural products, moracins O and P, as leads for development of HIF-1α inhibitor. ⺠We examined structure-activity relationship study of benzofuran based moracin derivatives using cell-based HRE assay. ⺠The primary activity of the represented compound was confirmed by biochemical methods. ⺠In this study we conclude that 2-arylbenzofuran ring and the (R)-configuration of the core scaffold is important for activity.
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Authors
Yan Xia, Yinglan Jin, Navneet Kaur, Yongseok Choi, Kyeong Lee,