Article ID Journal Published Year Pages File Type
7803124 European Journal of Medicinal Chemistry 2011 8 Pages PDF
Abstract
► Four-featured ligand-based pharmacophore model using most active renin inhibitors. ► Eight-featured structure-based pharmacophore model based on active site residues. ► Two important water molecules were also included during model generation. ► Hits with better potential were identified to be used in renin inhibitor design. ► Further optimization of the identified hits will improve their binding.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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